Health & Research Projects

2013 Science & Research Report
2013 Science & Research Report
VP Science Annual Report 2014.pdf
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Grant: 01418: PET 2.0: Providing Engineered T-cells (PET)
Grant: 01418: PET 2.0: Providing Engineered T-cells (PET)
The purpose of this grant is to develop a treatment for canine B-lineage NHL using autologous canine T cells which have been non-virally genetically modified using the Sleeping Beauty (SB) transposase/transposon gene transfer system (Figure 2) to express a canine chimeric antigen receptor (cCAR, Figure 1) that recognizes and targets the canine B-cell marker, CD20. The goal of specific aim 1 is to develop a panel of three canine CD20-specific cCARS for fullycompetent T-cell activation.
01418 PET 2.0.pdf
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