Progressive retinal degeneration (PRA) has been cited as occurring in over 100 breeds of dog. With one exception, PRA in all breeds studied so far has been described as an autosomal recessive disorder. read more →

Epilepsy is a common disease causing seizures in dogs. It is reported that between 0.5% – 5% of all dogs will develop epilepsy in their lifetime. A genetic basis has been proven in Beagles, Dachshunds, German Shepherds, Keeshonds, and Belgian Tervurens.1 There are many breeds, including English Springer Spaniels, with a high incidence of epilepsy, which are suspected to have a genetic component. read more →

02 Aug 2011
August 2, 2011

Seizure Research Abstracts

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Epilepsy is one of the most common diseases of the nervous system in dogs. The effects of repeated seizures can be devastating physically for the affected dogs and emotionally for the people who care for them. read more →

Phosphofructokinase (PFK) deficiency is an inherited disease that affects both the field trial and show lines of English Springer Spaniels. M-PFK is an enzyme required for the metabolism of glucose into useable energy. Without the PFK enzyme, some cells, such as muscle cells and red blood cells, cannot produce adequate energy for their needs. Therefore, affected dogs display the following intermittent, clinical signs: weakness, lethargy, exercise intolerance, poor performance, muscle cramps, anemia, jaundice, and dark-colored urine. Dark-colored urine, a hallmark of this disorder, usually appears after strenuous exercise or after excessive barking, panting, and heat exposure. read more →